Abstract: Drought, cold, salt and so on are the common adverse factors in the growth and development of crops. The growth and yield of crops are affected by these adverse factors, so more and more researchers are keen on the research of crop resistance to stress. LEA protein （late embryonic development rich protein） belongs to stress response protein, which is widely found in plants. This article is a brief review of the distribution, classification and function of LEA protein and the reearch progress of LEA protein in the process of crop resistance.