Abstract: Recently, the data reveal that many exogenous compounds from process of human production and life in vivo , analog or antagonize physiological role of natural hormones, were released into enviroment, and existed for long time. These exogenous compounds could directly or indirectly be accumulated in animals, and they can bond with hormone receptor, which led to nervous system disorders, endocrine disorders, weakened immune system and reproductive abnormalities, developmental toxicity, embryo toxicity, developing cancer and immunosuppressive diseases. Once the substances, named as endocrine secretion interferent, enter into organism, it can interfer endocrine secretion system and take effect on exist and reproductive. In the paper, the toxicity effect of estrogens from environment on male reproductive was reviewed.