K（Ca）3.1通道与血管功能的研究进展

doi:10.12160/j.issn.1672-5190.2011.05.007

畜牧与饲料科学 ›› 2011, Vol. 32 ›› Issue (5): 13-13.doi: 10.12160/j.issn.1672-5190.2011.05.007

K（Ca）3.1通道与血管功能的研究进展

杨柳

北京航空航天大学生物与医学工程学院,北京100191

出版日期:2011-05-20 发布日期:2011-05-20
通讯作者: 杨柳
作者简介:杨柳（1986-），女，硕士，主要研究方向为细胞生物学。

Research Advances on K_（Ca）3.1 Channels and Functions of Blood Vessel

YANG Liu （College of Biological Science and Medical Engineering,Beijing University of Aeronautics and Astronautics,Beijing 100191,China）

Online:2011-05-20 Published:2011-05-20

摘要/Abstract

摘要： 研究表明,在促进血管疾病发展的众多细胞类型中,如T细胞、B细胞、内皮细胞、成纤维细胞、巨噬细胞以及去分化的平滑肌细胞,KCa3.1都起到了一定的作用。生理上,KCa3.1已被证明在乙酰胆碱及内皮源性超极化因子（EDHF）介导下发生超极化,从而发挥控制血压的作用。病理上,KCa3.1异常则可导致血管平滑肌细胞增殖迁移。因此,从KCa3.1在内皮细胞及平滑肌细胞两方面对其作用作一总结,并对KCa3.1通道的研究进展进行综述。

Abstract: KCa3.1 has been characterized in numerous types of cells that contribute to the development of vascular disease,such as T-cells,B-cells,endothelial cells,fibroblasts,macrophages and dedifferentiated smooth muscle cells（SMCs）.Physiologically,the hyperpolarization of KCa3.1 has been demonstrated to be induced by acetylcholine and endothelium-derived hyperpolarizing factor （EDHF）,so as to control the blood pressure.Pathophysiologically,the abnormity of KCa3.1 can cause the proliferation and migration of vascular SMCs.The roles of KCa3.1 in EC and SMCs were summarized and the research advances of KCa3.1 channel were reviewed.

中图分类号:

Q463

杨柳. K（Ca）3.1通道与血管功能的研究进展[J]. 畜牧与饲料科学, 2011, 32(5): 13-13.

K（Ca）3.1通道与血管功能的研究进展

Research Advances on K_（Ca）3.1 Channels and Functions of Blood Vessel

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