Abstract: [Objective] The research aimed to observe and evaluate the damage model of gastric mucosa in diabetic rats. [Method]The damage model of gastric mucosa in diabetic rat produced by intraperitoneal injection of streptozotocin （STZ）in combination with 30% ethanol. The clinical symptoms, blood glucose,body weight, weight index and pathological changes of each organ were dynamically observed. [Result] The success rate of diabetes model and damage model of diabetic gastric mucosa were 84% and 64% respectively. The rats in model group became thin, the weight of heart,liver,spleen,pancreas decreased, pancreatic weight index decreased in the fourth week, but heart,liver,kidney weight indices rose at each time point, with extremely significant differences with normal group （P 0.01）. The pancreas, stomach and kidney of rats in model group had pathological changes. [Conclusion] The damage model of diabetic rat gastric mucosa could be successfully induced by intraperitoneal injection method of STZ in combination with ethanol.