Abstract: Effect of probiotics combination of antibiotics in the practical application of chicken producing,providing reference for actual production.The test is set up two groups randomly and four replicates in treatment, each replicate had 18360 chicken. Contrasting group is fed with basic proportion grain ration with antibiotics,the groups for experiment are fed with the basic proportion grain ration with antibiotics and proboscis in water, Probiotics are added into basic proportion grain ration in lOg/ton water,Test deadline is 42 days. The result of the research shows：The groups for experiment can increase significantly average weight of 5,6 week,the increasing weight per day and the productiveness of fodder in whole term （P 〈 0.05 ）,and no effeeting for the rate of slaughter each stage and in whole period.The groups for experiment can improve significantly the rate of chest muscle rate（P 〈 O.05）,but there are no significant influence in slaughter rate half net carcass rate,the whole net carcass rate and the leg muscle rate.The groups for experiment could dramatically increase economic benefits. The results indicated that the compatibility of prohiotics and antibiotics in drinking water can promote the growth of flesh chickens,improve the carcass quality, increase economic benefit.