Abstract: The paper is about magnetic stabilized fluidized bed reactor （MSFB） used in the treatment of sulphate-containing waste water. The acclimated sulphate reducing bacteria （SRB） group was put in sulphate reducing bacteria （anMSFB） filled with magnetic porous polystyrene microbeads （MPB）. The start-up of the system was operated using immersing - carriers- to- form- biofilm method. Then, the simulated waste water was flowed in to reach the stabilized loading operation. The optical microscopy and the scanning electron microscopy were used to investigate the biomass and biofilm formation in anMSFB. The effects of temperature and pH on the removal efficiency of SO4^2- were studied, and the SO4^2- degradation kinetics equation of anMSFB was determined. The bed height of MPB in anMSFB was deduced out theoretically according to the certain influent waste water concentration and desulphurization efficiency.The study has laid a foundation for MSFB with immobilized microorganism applied in the treatment of sulphate-containing waste water.