Abstract: As model organism ,A spergillus nidulans, a kind of filamentous fungi, possesses much more advantages compared to animals. The plasmodieresis of cell is the hotspot in recent biological research, and plasmodieresis of the filamentous fungi is achieved by the formation of septum. During the study on the plasmodieresis of Aspergillus nidulans, a regulatory pathway has been found. Various proteins were involved in this pathway, and played an important role in the regulation of plasmodieresis of Aspergillus nidulans . This article summed up the researches on the plasmodieresis ofAspergillus nidulans from this angle, which will offer the reference for the further study and use of A spergillus nidulans.