黄连解毒汤改善胰岛素抵抗与治疗2型糖尿病研究进展

doi:10.12160/j.issn.1672-5190.2025.02.012

摘要/Abstract

摘要： 黄连解毒汤出自《外台秘要》,作为清热解毒代表方剂,具有清泻三焦实火之效。2型糖尿病（Type 2 diabetes mellitus,T2DM）是以胰岛素抵抗（insulin resistance,IR）为关键病理特征的慢性代谢性疾病,严重威胁人类健康。围绕黄连解毒汤改善IR这一核心,系统综述其治疗T2DM的研究进展：①黄连解毒汤通过抗炎、抗氧化、抗内质网应激以及保护线粒体功能来改善IR的研究现状。②黄连解毒汤治疗T2DM的作用机制,以及其有效成分与结合靶点的研究现状。③黄连解毒汤治疗T2DM的临床应用情况。现有研究表明,黄连解毒汤治疗T2DM已取得较好疗效。然而,该方成分复杂,其各成分协同作用机制以及其不良反应的量化研究仍有待深入,基于此,整合近年相关文献,旨在为黄连解毒汤治疗T2DM的深入研究及临床合理应用提供参考。

关键词: 黄连解毒汤, 胰岛素抵抗, 2型糖尿病

Abstract: Huanglian jiedu Decoction, first recorded in Wai Tai Mi Yao, is a representative formula for clearing heat and detoxifying, known for its efficacy in purging excessive heat from San Jiao （Triple Burner）. Type 2 diabetes mellitus （T2DM）, a chronic metabolic disease, is primarily characterized by insulin resistance （IR） and poses a serious threat to human health. Focusing on the core role of Huanglian jiedu Decoction in improving IR, this review systematically summarizes the research progress in its application for T2DM treatment：①Current studies on the mechanisms by which Huanglian jiedu Decoction ameliorates IR through anti-inflammatory, antioxidant, alleviation of endoplasmic reticulum stress, and effects of mitochondrial function protection; ②Current studies on the mechanisms by which Huanglian jiedu Decoction treats T2DM, including research on its active components and their binding targets; ③Clinical applications of Huanglian jiedu Decoction in the treatment of T2DM. Existing research indicates that Huanglian jiedu Decoction has shown promising therapeutic effects in treating T2DM. However, due to the complexity of its components, the synergistic mechanisms of its components and the quantitative studies of adverse reactions require further investigation. By integrating recent literature, this review aims to provide a reference for in-depth research and rational clinical application of Huanglian jiedu Decoction in the treatment of T2DM.

Key words: Huanglian jiedu Decoction, insulin resistance, type 2 diabetes mellitus

中图分类号:

R587.1
R286

王月, 高世勇. 黄连解毒汤改善胰岛素抵抗与治疗2型糖尿病研究进展[J]. 畜牧与饲料科学, 2025, 46(2): 95-108.

WANG Yue, GAO Shiyong. Research Progress of Huanglian jiedu Decoction in Ameliorating Insulin Resistance and Treating Type 2 Diabetes Mellitus[J]. Animal Husbandry and Feed Science, 2025, 46(2): 95-108.

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