CpG-ODN作为免疫耐受诱导剂的研究进展

doi:10.12160/j.issn.1672-5190.2022.04.004

畜牧与饲料科学 ›› 2022, Vol. 43 ›› Issue (4): 19-24.doi: 10.12160/j.issn.1672-5190.2022.04.004

CpG-ODN作为免疫耐受诱导剂的研究进展

李晓奇,栗林,贾淑萍,王凤武

内蒙古自治区农牧业科学院，内蒙古呼和浩特 010031

收稿日期:2022-04-01 出版日期:2022-07-30 发布日期:2022-07-21
通讯作者: 王凤武（1973—），男，副研究员，博士，主要从事动物干细胞与免疫生物技术研究与应用工作。
作者简介:李晓奇（1972—），女，畜牧师，主要从事畜牧技术推广工作。
基金资助:
内蒙古自治区科技计划项目“特色蒙兽药新产品开发及标准化生产关键技术研究与应用”(2019GG347);内蒙古农牧业创新基金项目“复方黄芪绵羊含药血清生物学特性研究”(2022CXJJM07);内蒙古农牧业创新基金项目“绵羊干细胞免疫增强佐剂的研究与应用”(2019CXJJM09)

Research Progress of CpG-ODN as Immunological Tolerance Inducer

LI Xiao-qi,LI Lin,JIA Shu-ping,WANG Feng-wu

Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences，Hohhot 010031，China

Received:2022-04-01 Online:2022-07-30 Published:2022-07-21

摘要/Abstract

摘要：

免疫球蛋白E（immunoglobulin E，IgE）介导的过敏性疾病可以通过过敏原特异性免疫疗法（allergen-specific immunotherapy，ASIT）治疗。研究人员使用佐剂和免疫调节剂增强ASIT效果并提高其安全性。CpG-寡脱氧核苷酸（CpG-oligodeoxynucleotide，CpG-ODN）具有免疫耐受促进特性，是治疗过敏性疾病的理想免疫调节剂之一。研究发现，CpG-ODN的剂量对于通过募集浆细胞样树突状细胞（plasmacytoid dendritic cells，pDCs）促进免疫调节至关重要。低剂量CpG-ODN会引起炎症反应，高剂量CpG-ODN会引发免疫耐受。CpG-ODN对IgE介导的过敏性疾病表现出预防和治疗潜力。对CpG-ODN的种类、CpG-ODN对免疫细胞的影响以及CpG-ODN作为ASIT免疫耐受诱导剂的作用机制等方面的研究进展进行综述，以期为相关研究提供参考。

关键词: 过敏原特异性免疫疗法, CpG寡脱氧核苷酸, 过敏, 免疫耐受

Abstract:

Immunoglobulin E （IgE） - mediated allergic disorders can be treated with allergen-specific immunotherapy （ASIT）. Adjuvants and immunomodulators were utilized by researchers to improve the efficacy and safety of ASIT. CpG-oligodeoxynucleotide （CpG-ODN） is one of the best immunomodulators for the treatment of allergic disorders due to its ability to promote immunological tolerance. The doses of CpG-ODN were found to be critical for promoting immune regulation through the recruitment of plasmacytoid dendritic cells （pDCs）. Low doses of CpG-ODN elicited inflammatory responses while high doses of CpG-ODN triggered immunological tolerance. CpG-ODN has potential for the prevention and treatment of IgE-mediated allergic disorders. This paper reviews the research progress of the types of CpG-ODN, their effects on immune cells, and the mechanism of CpG-ODN as ASIT immunological tolerance inducer, in hoping to serve as references for related researches.

Key words: allergen-specific immunotherapy, CpG-oligodeoxynucleotide, allergy, immunological tolerance

中图分类号:

S852.4

李晓奇, 栗林, 贾淑萍, 王凤武. CpG-ODN作为免疫耐受诱导剂的研究进展[J]. 畜牧与饲料科学, 2022, 43(4): 19-24.

LI Xiao-qi, LI Lin, JIA Shu-ping, WANG Feng-wu. Research Progress of CpG-ODN as Immunological Tolerance Inducer[J]. Animal Husbandry and Feed Science, 2022, 43(4): 19-24.

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CpG-ODN作为免疫耐受诱导剂的研究进展

Research Progress of CpG-ODN as Immunological Tolerance Inducer

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