畜牧与饲料科学 ›› 2009, Vol. 30 ›› Issue (10): 150-150.doi: 10.12160/j.issn.1672-5190.2009.10.074

• 药物科学 • 上一篇    下一篇

免疫佐剂的研究进展

夏芳[1] 罗满林[1,2] 郭林[2] 刘健[2] 赵志权[2]   

  1. [1]广东大华农动物保健品股份有限公司,广东新兴527400 [2]华南农业大学兽医学院,广东广州510642
  • 出版日期:2009-10-20 发布日期:2009-10-20
  • 通讯作者: 夏芳
  • 作者简介:夏芳(1982-),女,硕士,主要研究方向为兽医生物制品。

Advance on Immune Adjuvant

XIA Fang, LUO Man-lin, GUO Lin, LIU Jian, ZHAO Zhi-quan(1.Guangdong Dahuanong Animal Health Products Co.,Ltd, Xinxing 527400, China; 2. Veterinary Medicine College, South China Agricultural University, Guangzhou 510642, China)   

  • Online:2009-10-20 Published:2009-10-20

摘要: 佐剂在改进免疫应答、提高免疫效应中发挥着重要作用。佐剂可以改变正常的免疫机能,吸引大量的巨噬细胞以吞噬抗原:改变抗原的构型,使抗原物质降解并加强其免疫原性;延长抗原在组织内的储存时间,使抗原缓慢降解和缓释,并发挥免疫细胞间协同作用。就几种常用的疫苗佐剂及DNA疫苗佐剂的应用进行了综述.

Abstract: It takes the important role in improving and enhancing immune response for adjuvant. Adjuvant not only can change immune function and recruit macrophages to swallow antigens (Ag), but also it can change configuration of Ag, and promote its decrease and enhance its immunogenicity. Even it can extend the stored time for Ag in texture, and educe immune cells to produce synergistic effect. Based on the above mentioned, the several common adjuvant and DNA vaccine adjuvant were introduced in the article.

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