Abstract: The Brachyury gene is a transcription factor encoded by the T-box gene family,which has been found in many animals including coelenterates.It plays an important role in regulating embryonic development,cell migration and other aspects of the organism.Its function also involves certain physiological processes such as organ formation during embryonic development.It has been found that Brachyury gene is directly associated with human tumor diseases,the development of chordal cord and the abnormal growth of tail type in animals.In this paper,the research progress of involvement of Brachyury gene in tumor disease and formation of short tail traits in animals was reviewed.