黄连解毒汤改善胰岛素抵抗与治疗2型糖尿病研究进展

doi:10.12160/j.issn.1672-5190.2025.02.012

Abstract

Abstract: Huanglian jiedu Decoction, first recorded in Wai Tai Mi Yao, is a representative formula for clearing heat and detoxifying, known for its efficacy in purging excessive heat from San Jiao （Triple Burner）. Type 2 diabetes mellitus （T2DM）, a chronic metabolic disease, is primarily characterized by insulin resistance （IR） and poses a serious threat to human health. Focusing on the core role of Huanglian jiedu Decoction in improving IR, this review systematically summarizes the research progress in its application for T2DM treatment：①Current studies on the mechanisms by which Huanglian jiedu Decoction ameliorates IR through anti-inflammatory, antioxidant, alleviation of endoplasmic reticulum stress, and effects of mitochondrial function protection; ②Current studies on the mechanisms by which Huanglian jiedu Decoction treats T2DM, including research on its active components and their binding targets; ③Clinical applications of Huanglian jiedu Decoction in the treatment of T2DM. Existing research indicates that Huanglian jiedu Decoction has shown promising therapeutic effects in treating T2DM. However, due to the complexity of its components, the synergistic mechanisms of its components and the quantitative studies of adverse reactions require further investigation. By integrating recent literature, this review aims to provide a reference for in-depth research and rational clinical application of Huanglian jiedu Decoction in the treatment of T2DM.

Key words: Huanglian jiedu Decoction, insulin resistance, type 2 diabetes mellitus

CLC Number:

R587.1
R286

WANG Yue, GAO Shiyong. Research Progress of Huanglian jiedu Decoction in Ameliorating Insulin Resistance and Treating Type 2 Diabetes Mellitus[J]. Animal Husbandry and Feed Science, 2025, 46(2): 95-108.

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Research Progress of Huanglian jiedu Decoction in Ameliorating Insulin Resistance and Treating Type 2 Diabetes Mellitus

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