Abstract: The aim of the present study was to evaluate the preventive and therapeutic effects of compound traditional Chinese medicines with different administrative methods against chicken infectious bursa disease （IBD） in broilers. A total of 5 600 healthy white feather broilers were chosen and averagely assigned into preventive experiment group and therapeutic experiment group; six screened compound traditional Chinese medicines were used in preventive experiment （compound Ⅰ-Ⅲ） and therapeutic experiment （compound Ⅳ-Ⅵ）; a total of four administrative methods, including feeding administration, drinking administration, atomization administration and comprehensive administration, were used in both preventive experiment and therapeutic experiment; there were five groups for each administrative method, including three experimental groups and two control groups, and one compound traditional Chinese medicine was administrated for each experimental group; the morbidity and mortality of the broilers caused by IBD were observed in preventive experiment, and the healing rate and mortality of the broilers caused by IBD were observed in therapeutic experiment. The results showed that in preventive experiment, the compound Ⅱ had an overall good performance in all of the four administrative methods; the preventative efficacy of compound Ⅱ against IBD was similar to that of vaccination; the IBD incidence of the broilers administrated with compound Ⅱ by the four administrative methods were all below 20%; in therapeutic experiment, the best comprehensive curative effect was observed in compound Ⅴ; when the IBDV challenged broilers were given compound Ⅴ by drinking administration method and comprehensive administration method, the healing rate was similar rate to that of the broilers treated with antibiotics＋antiviral agents; generally, for all of the three compound traditional Chinese medicines for therapeutic use, drinking administration method and comprehensive administration method had better curative effect compared to feeding administration method and atomization administration. The combined data suggested that the natural compound traditional Chinese medicine had certain preventive and therapeutic effects against IBD in broilers.