铅对骨代谢生化指标影响的研究进展

doi:10.12160/j.issn.1672-5190.2021.05.008

Abstract

Abstract: Lead is a heavy metal pollutant and is extremely harmful to human and animal health. Many studies have found that bone is the important target organ of lead toxicity. Lead accumulates in bone after absorption in body which results in osteoporosis. In clinic, the damages of lead to bone are mainly evaluated by some biochemical indexes of bone metabolism such as PINP, OPG, β-CTX and CT. In recent years, studies have shown that biochemical indexes of bone metabolism revealed the bone metabolism state and bone conversion rate, which is of great significance for the differential diagnosis of osteoporosis. In this paper, the research advances on the effects of lead on biochemical indexes of bone metabolism are reviewed, in hoping to provide references for investigation of the molecular mechanism underlining the impacts of lead on bone metabolism.

Key words: lead exposure, bone metabolism, bone formation markers, bone resorption markers, calcium and phosphorus metabolism

CLC Number:

S859.87

LIN Lu-xi, XU Ting-ting, CAO Qin-qin, YUE Ke, ZHANG Chao-dong, ZHENG Jing-jing, HE Xiu-yuan, HUANG Shu-cheng. Research Advances on the Effects of Lead on Biochemical Indexes of Bone Metabolism[J]. Animal Husbandry and Feed Science, 2021, 42(5): 45-50.

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Research Advances on the Effects of Lead on Biochemical Indexes of Bone Metabolism

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