Abstract: The morphological structures and distribution densities of 2 immunoreactive cells with 5-hydroxytryptamine （5-HT） and somatostatin （SS） in the digestive tract of blue fox were studied by immuno-histochemical SP method. The resuhs indicated that most of the 2 immunoreactive ceils in digestive tract showed to be round, oval shape or cone-shape, they were mainly distributed among gastric gland epithelia, intestinal epithelia and intestinal gland epithelia fixedly. The immunoreactive cells with 5-HT were most in colon, secondary in rectum and jejunum, less in fundus gland region, duodenum, ileum and pyloric gland region, not found in esophagus, cardiac gland region and cecum. The immunoreactive cells with SS appeared in pyloric gland region largely and were not found in esophagus, cardiac gland region and cecum. Based on their shapes, it was speculated that these 2 immunoreactive cells in the digestive tract of blue fox had 2 secretion functions of endocrine and exocrine.