Abstract: Bisphenol A（BPA） is the monomer used to synthesize polycarbonate and epoxy resin,and it has been widely applied to produce package of food and drink,dental fillers,and other plastic products.The extensive application of plastics results in higher levels of BPA in environment and causes environmental pollution and potential treats to human.To investigate the effects of exposure to BPA on brain and behaviors during perinatal period,the female dams were gavaged with BPA respectively at a dose of 2 and 200 μg/kg every day from gestational Day 3 to postnatal Day 21.The behaviors of 70-day-old female offspring were observed by new cage test.The results indicated that the female offspring which were born by the dams given BPA at a dose of 200 μg/kg had inhibited exploration ability and significantly decreased duration and frequency of locomotion,when compared with the control group.Therefore,exposure to BPA during perinatal period can inhibit exploration and locomotion ability of female mice,and this effect may be caused by estrogen.