Abstract: The historical survey, clinical examination, pathological examination and laboratory examination were conducted in 21 sheep with suspected eperythrozoonosis. The confirmed diagnosis of eperythrozoonosis was made according to the combined examination results. The diseased sheep were administered with diminazene by intramuscular injection, and traditional Chinese medicine Artemisia annua was supplemented in sheep feed. Meanwhile, treatment measures such as anti-bacteria, stomach strengthening, energy supplement and nutrition enhancement were also made. The cure rate was 90.47% by adoption of the combined therapy measures.