Abstract: To understand the physiological responses of different leaves of Begonia sempeflorens to Pb stress, the effects of different soil Pb concentrations on the activities of physiological characteristics in different leaves were studied in a pot experiment with different Pb treatments. The results showed that under Pb stress, the SOD and CAT and POD activity increased firstly and then decreased; POD activity and cell membrane relative permeability and malondialdehyde （MDA） increased gradually along with soil drought stress proceeding. The response of fresh leaves to soil Pb stress was more sensitive than that of old leaves and mature leaves.