Abstract: Ion beam biotechnology was invented by our scientists in the late 1980s.With advantages of high rate,wide range and quickly stable of variation,stable,reliable and easy technology, it is widely used in plants and microbial induce mutation breeding. In edible fungus mutation breeding aspect, this technology made a lot of technical progress, especially in the functional areas of edible mushroom.The developing progress and the future of ion beam biotechnology in edible mushroom had been described in this paper.