Abstract: Channel catfish enteric septicemia is its farming period a common of bacteria sexual fish disease, In Southern Region China the disease occurs common, in Inner Mongolia Autonomous Region this disease of reported is Was first reported , the treatment of the disease Were used oxytetracycline, florfenicol, salt acid enrofloxacin 3 species antibiotics, and combined oral herbal, and outside poured poly dimension ketone iodine and Yi health bacteria regulation water of method, is good to control has the disease, on future I district control the disease has guide role.