Abstract: ＂Superbugs＂ is a general term of multi-drug resistant bacteria. The new type of ＂superbugs＂ is a bacteria with resistance gene new delhi metallo-β-1aetamase-1. Recently, researchers have found that plasmids carrying a new metallo-β- lactamase gene, blaNDM-l,and many other antibiotics resistance genes can easily spread through bacterial populations and almost all β-lactam antibiotics could be hydrolyzed, It is a threat to the human health. The new ＂superbugs＂ and its route of spread as well as a preventive measure against ＂superbugs＂to respond the attack of ＂superbugs＂ on mankind were introduced in this paper.