Abstract: The stress resistance, ecological adaptability and habitat suitability of crops have become one of the key problems in breeding. The cotton variety Xinluzhong 42 were planted in the main cotton planting area in the west of Inner Mongolia to select suitable planting area, the different ecological functional zones of the growth period of growth period, agronomic traits, yield traits and yield features of skin were determined. The results showed that Xinluzhong 42 seed cotton yield and lint yield were the highest for 5 427.3 kg]hm2＇ 2 315.4 kg/hm2 in Ejin Banner; comprehensive analysis, Xinluzhong 42 in the western region of Inner Mongolia,order of suitable planting area Ejina Banner, Alxa Right Banner, Alxa Left Banner, Uxin Banner. Ecological adaptability and habitat suitability showed the geographical distribution pattern of decreasing from Northwest to Southeast;To Dengkou County because of the frost before boll opening rate was not up to the standard still need to further test.