Abstract: Nineteen cases of enteritis type canine parvovirus disease in an animal hospital were diagnosed based on the analysis of the treatment protocol and experience. Among the cases, two of them were mixed infection with parasite, four of them were mixed infection with coronavirus, and other 13 cases were simple infection of parvovirus. The sufficient and prompt employment of antiviral drugs combining with anti-inflammation, fluid infusion and correcting the unbalance between acid and alkali were effective treatment measures for canine parvovirus disease.