Abstract: Biochemistry is an important basic discipline which focuses on the essence of life activities. Due to its abstract knowledge and complicated content, Biochemistry is commonly considered as a ＂hard to teach and hard to learn＂ discipline. ＂Teaching＂ and ＂Learning＂ are two basic elements of the teaching process, they are independent and unified. In teaching process of Biochemistry, both of the ＂Teaching＂ of teachers and the ＂Learning＂ of undergraduates should be emphasized. The teaching reform in theoretical and experimental courses of Biochemistry is expected to be taken and the initiative of undergraduates′ selflearning is supposed to be strengthened, so as to improve the teaching quality and to solve the problem of ＂hard to teach and hard to learn＂ of Biochemistry.