血小板衍生因子A的生理功能研究进展

doi:10.12160/j.issn.1672-5190.2021.04.010

畜牧与饲料科学 ›› 2021, Vol. 42 ›› Issue (4): 49-53.doi: 10.12160/j.issn.1672-5190.2021.04.010

血小板衍生因子A的生理功能研究进展

吴子贤¹, 李蕴华¹, 张斌², 张军³, 赵艳红⁴, 刘佳森¹

1.内蒙古自治区农牧业科学院畜牧研究所,内蒙古呼和浩特 010031;
2.武川县家畜改良站,内蒙古武川 011700;
3.鄂尔多斯市杭锦旗动物疫病预防控制中心,内蒙古杭锦旗 017400;
4.内蒙古农业大学动物科学学院/内蒙古自治区动物遗传育种与繁殖重点实验室,内蒙古呼和浩特 010018

收稿日期:2021-03-01 出版日期:2021-07-30 发布日期:2021-08-25
通讯作者: 刘佳森（1978—）,男,研究员,博士,主要研究方向为动物分子育种与表观遗传调控。
作者简介:吴子贤（1994—）,女,硕士,主要研究方向为动物分子遗传育种。
基金资助:
国家自然科学基金项目（31560624）; 内蒙古自然科学基金项目（2020LH03020,2015MS0381）; 内蒙古农牧业科技创新基金项目（2017CXJJM01-3）

Research Advances on Physiological Functions of Platelet-derived Growth Factor A

WU Zi-xian¹, LI Yun-hua¹, ZHANG Bin², ZHANG Jun³, ZHAO Yan-hong⁴, LIU Jia-sen¹

1. Animal Husbandry Institute, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China;
2. Livestock Improvement Workstation of Wuchuan County,Wuchuan 011700,China;
3. Center for Animal Disease Control and Prevention of Hanggin Banner of Ordos City,Hanggin Banner 017400,China;
4. Inner Mongolia Key Laboratory of Animal Genetics,Breeding and Reproduction,College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China

Received:2021-03-01 Online:2021-07-30 Published:2021-08-25

摘要/Abstract

摘要： 血小板衍生因子A（platele-derived growth factor A,PDGFA）是PDGF家族中的一种多肽,具有促进细胞生长、刺激细胞与细胞间质相互作用、影响毛囊生长的功能。从PDGFA的蛋白结构、主要基因表达通路Wnt、SHH、BMP和在皮肤、肺部以及绒毛生长中的作用进行综述,探讨PDGFA在毛囊生长和周期维持中发挥的重要作用,以期为进一步研究绒毛生长机理提供参考。

关键词: PDGFA基因, 结构和表达, 表达通路, 生理功能, 毛囊生长

Abstract: Platelet-derived growth factor A （PDGFA） is a kind of polypeptides in the PDGF family, which has the functions of promoting cell growth, stimulating the interactions between cells and intercellular substances, and influencing wool follicle growth. This paper reviews the protein structure of PDGFA, the main expression pathways of Wnt, SHH and BMP of PDGFA, and the roles of PDGFA in skin, lung and wool growth. Furthermore, the important roles of PDGFA in wool follicle growth and cycle maintenance are elaborated, in hoping to provide a basis for further researches on mechanisms of wool growth.

Key words: PDGFA gene, structure and expression, expression pathway, physiological functions, wool follicle growth

中图分类号:

Q592.1

吴子贤, 李蕴华, 张斌, 张军, 赵艳红, 刘佳森. 血小板衍生因子A的生理功能研究进展[J]. 畜牧与饲料科学, 2021, 42(4): 49-53.

WU Zi-xian, LI Yun-hua, ZHANG Bin, ZHANG Jun, ZHAO Yan-hong, LIU Jia-sen. Research Advances on Physiological Functions of Platelet-derived Growth Factor A[J]. Animal Husbandry and Feed Science, 2021, 42(4): 49-53.

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血小板衍生因子A的生理功能研究进展

Research Advances on Physiological Functions of Platelet-derived Growth Factor A

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