整合素通过PI3K/Akt信号通路调控畜禽骨骼健康的研究进展

doi:10.12160/j.issn.1672-5190.2024.01.018

摘要/Abstract

摘要： 骨骼是脊椎动物中坚硬的结缔组织,具有构成机体基本支架、保护脏器、支撑体重和维持运动的作用。骨骼发育主要是通过膜内成骨和软骨内骨化完成的,该过程由多种调控因子组成的复杂调控网络共同发挥作用以维持畜禽骨骼健康。整合素（integrin）是细胞膜上的一种介导细胞-基质相互作用的跨膜受体,不仅具有引起细胞黏附的作用,还能够通过双向传递细胞内外的信号引发机体相应反应。整合素能够调控多条信号通路,包括磷脂酰肌醇3-激酶/蛋白激酶B（phosphatidylinositol 3-kinase/protein kinase B,PI3K/Akt）信号通路,在维持畜禽动物骨骼健康方面发挥重要作用。PI3K/Akt信号通路是由酶联受体介导的能够调节细胞生命活动的信号通路,能通过炎症、自噬、凋亡等作用调节软骨代谢平衡,对维持骨骼健康具有重要意义。综合国内外关于畜禽骨代谢、整合素和PI3K/Akt信号通路之间关系的研究进展,从整合素对畜禽骨代谢的影响、PI3K/Akt信号通路对畜禽骨代谢的影响以及整合素通过PI3K/Akt信号通路对骨代谢的影响三方面进行综述,以期为探究整合素通过PI3K/Akt信号通路在畜禽骨健康调控中的关键作用提供理论基础。

关键词: 整合素, PI3K/Akt信号通路, 骨代谢, 骨骼健康

Abstract: Bone is the hard connective tissue in vertebrates, which has the functions of constituting the basic scaffolding of the body, protecting organs, supporting body weight and maintaining locomotion. Skeletal development is mainly accomplished through intramembranous osteogenesis and endochondral ossification, and is a process in which a complex regulatory network of multiple regulatory factors works together to maintain bone health in livestock and poultry. Integrin is a trans-membrane receptor on the cell membrane that mediates cell-matrix interactions. It not only has the role of causing cell adhesion, but is also capable of triggering corresponding responses in the body through bidirectional transmission of intracellular and extracellular signals. Integrin regulates multiple signaling pathways, including phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway, and plays an important role in maintaining bone health in livestock and poultry. PI3K/Akt signaling pathway is mediated by enzyme-linked receptors and is capable of regulating cellular life activities. It can regulate cartilage metabolism homeostasis through inflammation, autophagy and apoptosis, which is of great importance for maintaining bone health. Based on the research progress in the relationships among bone metabolism, integrin and PI3K/Akt signaling pathway in livestock and poultry both domestically and internationally, this article reviews the effects of integrin and PI3K/Akt signaling pathway on bone metabolism, and the impacts of integrin on bone metabolism via PI3K/Akt signaling pathway, in hoping to provide theoretical bases for exploring the key role of integrin in regulating bone health in livestock and poultry via PI3K/Akt signaling pathway.

Key words: integrin, PI3K/Akt signaling pathway, bone metabolism, bone health

中图分类号:

路亚男, 丁文丽, 岳涛静, 徐博文, 黄淑成. 整合素通过PI3K/Akt信号通路调控畜禽骨骼健康的研究进展[J]. 畜牧与饲料科学, 2024, 45(1): 120-128.

LU Ya′nan, DING Wenli, YUE Taojing, XU Bowen, HUANG Shucheng. Recent Progress in the Roles of Integrin in Regulating Bone Health in Livestock and Poultry via PI3K/Akt Signaling Pathway[J]. Animal Husbandry and Feed Science, 2024, 45(1): 120-128.

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