畜牧与饲料科学 ›› 2011, Vol. 32 ›› Issue (1): 28-28.doi: 10.12160/j.issn.1672-5190.2011.01.013

• 遗传与繁育 • 上一篇    下一篇

NRAMP1基因的研究进展

薛尚军[1] 贾静敏[2] 刘宏[1] 石建中[1] 曹果清[2]   

  1. [1]山西省大同市种猪场,山西大同037000 [2]山西农业大学动物科技学院,山西太谷030801
  • 出版日期:2011-01-20 发布日期:2011-01-20
  • 通讯作者: 薛尚军
  • 作者简介:薛尚军(1952-),男,畜牧师,主要从事养猪生产与管理工作。 通讯作者:曹果清(1971-),女,教授,主要从事动物遗传育种的教学与研究工作。
  • 基金资助:
    山西省攻关项目(991016和20080311031); 科技部农业科技成果转化资金项目(2008GB2A300032)

The Progress of Natural Resistance Associated Macrophage Protein 1

XUE Shang-jun,JIA Jing-min,LIU Hong,SHI Jia-zhong,CAO Guo-qing(1.Datong Pig Breeding Farm,Datong 037000,China;2.College of Animal Science and Veterinary Medicine,Shanxi Agricultural University,Taigu 030801,China)   

  • Online:2011-01-20 Published:2011-01-20

摘要: 天然抗性相关巨噬蛋白(natural resistance associated macrophage protein 1,NRAMP1)与多种胞内菌如结核分枝杆菌、沙门氏杆菌和利什曼原虫等易感和抗性相关。综述了NRAMP1基因的结构特点、作用机理、表达调控及其与疾病的相关性,以期为应用于猪的抗病育种提供理论依据。

Abstract: Natural resistance associated macrophage protein 1 has been testified that it is correlation to resistance on a variety of intracellular bacteria such as Mycobacterium tuberculosis,Salmonella and Leishmania etc.In this paper,the structure characteristics of NRAMP1 gene,expression mechanism,regulation and correlation with disease was reviewed,it will provide the theoretical basis for breeding application in pig disease resistance.

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