Abstract: The aim of the present study was to understand the etiology of high content γ-GT in blood in northwest Tibet Cashmere Goat. In order to assess the association of the blood pressure, related diseases and stress factor with the high content γ-GT in blood in northwest Tibet Cashmere Goat, the goat individuals with high content γ-GT in blood were selected; the electronic sphygmomanometer was used to determine their blood pressure; the diseases of hepatitis B, hepatitis E, hepatic echinococcosis and cholelithiasis were diagnosed by ELISA kit method and liver biopsy; the stress test was carried out to observe the effect of the stress on the blood content of γ-GT. The results revealed that amongst the 25 selected goats with high content γ-GT in blood, 4 of them had high blood pressure, 11 of them were HEV-IgG positive, none of them were HBV antigen positive, 12 of them were Echinococcos granulsus antibody positive, 3 of them were subjected to cholelithiasis and choledocholithiasis, and 7 goats had high content γ-GT in blood after the stimulation of stress factor. The results suggest that the hepatitis and cholelithiasis caused by infections of hepatitis E virus and Echinococcos granulsus as well as the stress factor are the main etiology of high content γ-GT in blood in northwest Tibet Cashmere Goat.