白藜芦醇对家畜冻精品质影响的研究进展

doi:10.12160/j.issn.1672-5190.2025.04.013

摘要/Abstract

摘要： 家畜精液冷冻技术自20世纪发展至今已相当成熟,并与人工智能等现代技术深度融合,成为推动家畜繁育现代化、高效化及满足家畜产品需求的关键支撑,尤其在保存珍贵遗传资源、促进优良品种利用与跨区域交流方面价值显著。然而,冷冻-解冻过程引发的氧化应激损伤（如活性氧过量产生、抗氧化防御削弱）导致精子质膜变薄破损、顶体损伤及DNA完整性被破坏,严重制约解冻精液品质、受精潜能及家畜精液冷冻技术的广泛应用,进而阻碍优秀种畜传播和畜牧业可持续发展。文章系统评述了白藜芦醇改善冷冻-解冻后精子活力、质膜完整性、顶体状态及DNA稳定性等关键品质指标的效果,深入探讨其核心作用机制,包括显著降低活性氧水平、有效抑制脂质过氧化反应、提升精子内源性抗氧化酶活性,并分析其应用特性,特别是效果呈现的浓度依赖性及潜在协同效应。旨在阐明白藜芦醇在冷冻精液抗氧化方面的作用机理与应用价值,优化其保护液浓度并探索协同策略,以提升家畜精液冷冻保存效果,增强遗传资源保存与利用能力,推动畜牧业可持续发展。

关键词: 白藜芦醇, 抗氧化, 活性氧：冻精品质

Abstract: The cryopreservation of livestock semen has reached a mature stage of development since the 20th century and has been deeply integrated with modern technologies such as artificial intelligence, serving as a crucial support for advancing the modernization and efficiency of livestock reproduction and meeting the demands for livestock products. This technology is particularly valuable for preserving precious genetic resources, promoting the utilization of superior breeds, and facilitating cross-regional exchange. However, oxidative stress injuries induced by the freeze-thaw process, such as the excessive reactive oxygen species production and weakened antioxidant defenses, lead to thinning and damage of the sperm plasma membrane, acrosome impairment, and DNA integrity disruption. These effects significantly impair the quality and fertilization potential of thawed semen, and widespread application of cryopreservation technology, thereby hindering the dissemination of superior breeding stock and the sustainable development of animal husbandry. This review systematically evaluates the effects of resveratrol in improving key quality parameters of frozen-thawed semen, including sperm motility, plasma membrane integrity, acrosome status, and DNA stability. It further explores its core mechanism of action, including a significant reduction of reactive oxygen species levels, effective inhibition of lipid peroxidation, and enhancement of endogenous antioxidant enzyme activity in sperm. Additionally, the application characteristics of resveratrol, particularly its concentration-dependent effects and potential synergistic interactions, are analyzed. This review aims to elucidate the antioxidant mechanisms and application value of resveratrol in semen cryopreservation, optimize the concentration of resveratrol in cryoprotective media, and explore synergistic strategies to enhance the efficacy of livestock semen cryopreservation, thereby improving genetic resource preservation and utilization, and promoting the sustainable development of animal husbandry.

Key words: resveratrol, antioxidant, reactive oxygen species, cryopreserved semen quality

中图分类号:

S814.4

刘志远, 王志英, 付绍印. 白藜芦醇对家畜冻精品质影响的研究进展[J]. 畜牧与饲料科学, 2025, 46(4): 95-101.

LIU Zhiyuan, WANG Zhiying, FU Shaoyin. Research Progress on the Effects of Resveratrol on the Quality of Cryopreserved Livestock Semen[J]. Animal Husbandry and Feed Science, 2025, 46(4): 95-101.

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