Abstract: The aim of the present study was to assess the inhibitory effect of Pogostemon cablin on acetic acid-induced writhing in mice and to determine the analgesic effect of Pogostemon cablin.A total of 24 mice were randomly and averagely divided into Pogostemon cablin low-dose group,moderate-dose group,high-dose group and control group.The 0.25,0.5,1.0 g/（kg·BW） of Pogostemon cablin solutions were intragastricly administrated for the low-dose,moderate-dose and high-dose group,respectively,and saline was intragastricly administrated for the control group.The mice in treatment groups and control group subsequently received 20% of acetic acid solution by intragastric administration.The posture change and writhing times of the mice were recorded,and the analgesic rate was calculated.The results showed that after receiving 20% of acetic acid solution,the mice in high-dose group expressed mild abdominal pain symptoms and their counterparts in low-dose group exhibited severe symptoms and convulsed;the writhing times of high-dose group was very significantly less than that of low-dose group（P〈0.01）,and the writhing times of moderate-and low-dose group was significantly less than that of control group（P〈0.05）;the highest analgesic rate was observed in high-dose group（36.73%） and the lowest analgesic rate was observed in low-dose group（14.45%）.The combined data showed Pogostemon cablin had inhibitory effect on acetic acid-induced writhing in mice,expressing good analgesic effect with exhibited dose-effect relationship.