Abstract: The objective of this trial is to probe the effect of lipoic acid on rabbit＇s reproductive performance under heat stress. 20 female New Zealand rabbits were randomly divided into four groups, 5 replicates in every group was made with one rabbit in each replicate. The rabbits was respectively fed with the ration of 0 mg/kg fipoie acid in basal feed（control group）, and 200 mg/kg（treatment 1 ） ,400 mg/kg （treatment 2）,600 mg/kg （treatment 3）under the temperature （31.2±1.5） ℃. The results showed that： ①the average litter size among treatment 1, treatment 2, treatment 3 and control group were respectively （6.4±2.1）, （6.8±1.9）, （7.2±1.9） and （6.2±2.2）, there were a tendency that the average litter size increased with the lipoie acid concentration increasing in ration, and there was significant differeneebetween treatment 3 and control group （P〈0.05）; ②the average live litter size among treatment 1, treatment 2, treatment 3and control group were respectively （6.4±2.1）, （6.4±2.3）, （7.0±1.2）and （6.0±1.9）, there were a tendency that the average live litter size increased with the lipoic acid concentration increasing in ration , and there was significant difference between treatment 3 and control group （P〈0.05） ;③the average birth weight among treatment 1, treatment 2, treatment 3 and control group 1 were respectively （49.5±2.4） g, （48.2±2.4） g, （50.6±2.8） g and （45.7±5.0） g, the treatment 3 had significant difference compared with the control group （P〈0.05）. The conclusion could be made that it was better for reproductive performance with addition of lipoic acid in ration under heat stress, the optimal concentration of lipoic acid in ration was 600 mg/kg.