Abstract: With the development of crab -breeding,the disease continue to occur mainly due to environmental factors,pathogenic microorganisms,as well as farming techniques,therefore healthy breeding in crabs would be paid more attention in order to decrease the damage caused by diseases,improve survival rate and keep the increase of economic efficiency.This article on these three aspects of environmental factor,pathogenic microorganism and breeding technology provide an overview of the situation home and abroad,and summed up the crab disease causes.