Abstract: Goose paramyxovirus disease also known as goose paramyxovirus infection is caused by goose paramyxovirus type I, and it is a viral infectious disease characterized by the main clinical symptoms and pathological changes of digestive system and respiratory system. It has high morbidity and mortality and is a great threat to goose industry. The pathogenesis, epidemiology, clinical symptoms, pathological changes and diagnosis of paramyxovirus disease were introduced. Taking Wanxi white geese as an example, drug sensitivity test was performed, and integrated prevention and control measures were proposed in order to provide reference for avoiding the occurrence of this disease and reducing mortality.