Abstract: Osteoporosis is a general bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue, which lead to bone fragility and a consequent susceptibility to fracture. It is one of serious diseases, which endangers health of humans, particularly postmenopausal women and old men. In recent years, a lot of drugs have been developed for prevention and treatment of osteoporosis and also largely promote development of clinical research and theoretics of osteoporosis. This article summarizes the overall development in therapeutic drugs against osteoporosis.