Abstract: The anti-inflammatory and analgesic effect of self-made external Chinese traditional medicine cream were studied, so as to provide clinical basis for the treatment of sports injury by using Chinese medicine. The anti-inflammatory and analgesic effect of external Chinese traditional medicine cream was studied by using the methods of ear-swelling induced by xylene in mice, feet-swelling of mice induced by egg white,hot plate test and the acetic acid writhing test. The results showed that external Chinese traditional medicine cream could obviously inhibit the ear-swelling of mice induced by xylene and feet-swelling of mice induced by egg white（P0.01）, and it could enhance the pain threshold of mice in the hot plate test and the acetic acid writhing test（P0.01）. It was proved that external Chinese traditional medicine cream had good anti-inflammatory and analgesia effects.