Abstract: To investigate the impact of different weanling diets on expression pattern of Hypocreins Receptor 2 （HCRTR2） in intestine for weanlingpiglets,real-time quantitative reverse transcription PCR （RT-qPCR） was carried out to quantify HCRTR2 expression at age of 0,3,7 and 14 days in weanling piglets fed with the diets 30% milk protein substituted the whole protein （treatment 1 ） and the vegetable protein （treatment 2）.RT-qPCR result showed that HCRTR2 expressed in postnatal intestine of piglets during weanling. In the treatment 1,the expression level increased on day 3,7,14 compared with day 0 with 4.30,6.60 and 4.12 times higher respectively and expression on day 7 being highest.In the treatment 2,the expression level increased 1.44 and 4.50 times on day 7,14 while it decreased 0.71 times on day 3 compared with day 0. In conclusion,the different protein diets affect the expression pattern of Hypocreins Receptor 2 in intestine for weanling piglet.