Abstract: Sheep Brucellosis is a zoonotic infectious disease caused by Brucella, it is also one of the most serious harmful zoonoses in the world. Not only could it cause tremendous economic loss, but threatened People＇s safety. Combined with years of clinical experience, epidemic characteristics, clinical symptoms and pathological changes of sheep Brucellosis is described, effective prevention and control measures was put forward, to provide reference for prevention and control of sheep Brucellosis.