Abstract: The effects of serum with Valeriana jatamansi on the lymphocytes and macrophage of mice were studied by using MTT colorimetry. The effects of drug-containing serum on the energy metabolism level and phagocytosis of PMΦin mice were detected by using neutral red phagocytosis test. The results showed that the serum with V. jatamansi had certain promoting effects on the spleen lymphocyte transformation capability of mice. And the energy metabolism level and phagocytosis of PMΦ in mice were enhanced, so its immunity could be enhanced to some extent.