Abstract: Probiotics are active preparation, composed of living microorganisms. Researches showed that it has a variety of useful characters to animal health, such as good effect,no residues etc. Thus, it has become a research hotspot around the world, and many different products have been developed on the market. Probiotics show different biological activity, and play important roles in preventing disease, nutrition regulation, immune regulatory whether used alone or mixed on animal body. Therefore, it will become an inevitable trend that probiotics replace antibiotics in breeding livestock and poultry. The definition, origin and development of probiotics and progress on anti-disease nutrition of livestock and poultry breeding in recent years were reviewed.