Abstract: [ Objective ] The research aimed to study the nutrition and stress situations of perinatal sows. [ Method ] 15 new-born crossbred sows of Landrace ×Large White with the same batch were selected to collect blood samples on the 14-th day before parturition, the parturition day and the 14-th day after parturition. The levels of serum cortisol, haptoglobin, nonesterified fatty acid （NEFA）, glucose, insulin and urea were detected. [Result] The cortisol concentration in the serum of the parturition day was significantly higher than that of the 14-th day before parturition and the 14-th day after parturition （P〈0.01）. The concentration of haptoglobin in the serum of the parturition day increased by 25.81% than that of the 14-th day before parturition （P〈0.05）. The level of NEFA in the serum of the parturition day was 3.54 times of that of the 14-th day before parturition（P〈0.01 ）and 3.63 times of that of the 14-th day after parturition （P〈0.01）.The insulin level in the serum of the parturition day was significantly lower than that of the 14-th day before parturition and 14-thh day after parturition （P〈0.01）. The urea level of the parturition day was 1.46 times of that of the 14-th day before parturition （P〈0.01 ）and significantly lower than that of the 14-th day after parturition （P〈O.01 ）. [ Conclusion ] Perinatal sows were under the physiological conditions of high-intensity stress, deterioration of health status and negative nutrition balance.