Abstract: Sarcoptidosis is a parasites disease with strong infectiousness. Once the sarcoptidosis emerge in sheep flocks, it may cause lots of outbreak cases without taking proper isolation and treatment measures. In order to validate the effect of drugs used for sarcoptidosis treatment saled in the market, the traetment experiment was carried out in this study. The results showed that the rational employment of ivermectin, amitraz, diazinon, phoxim could effectively treat the sarcoptidosis in sheep flocks.