Abstract: Ultrasonic assisted methanol extraction technique was employed to extract thermopsiue from Thermopsis lanceolata, and the orthogonal experiment was conducted to optimize the extraction technology and to select the optimum extraction condition. The results showed that the optimum extraction condition was as followed： the methanol concentrations was 70%, the solid-liquid ratio （g/mL） was 1：20, the ultrasonic duration was 60 min, ultrasonic power was 500 W ,and the ultrasonic temperature was 60 ℃. The highest extraction rate reached 1.195%. It was proved that the ultrasonic assisted method was an effective and optimum technology for thermopsine extraction from Thermopsis lanceolata.