Abstract: [Objective]This study was aimed to evaluate the popularization value of early weaning scheme of Chinese Holstein calves in alpine area. [Methods]A total of 16 newborn（within 1 week） Chinese Holstein calves with similar body weight were selected and randomly divided into two groups with 8 calves for each group. The experimental group was weaned with the early weaning scheme, and the control group was weaned with the routine scheme. The experimental period lasted for 90 d. [Results]The results revealed that the daily weight gain of 60-day-old and 90-day-old calves in experimental group was significantly higher than that in control group（P〈0.05）; the weight gain of 90-day-old calves in experimental group was significantly higher than that in in control group（P〈0.05）; the diarrhea incidence of 30-day-old calves in control group was 100%, and the incidence of recurrence of diarrhea was 75%; the diarrhea incidence of 30-day-old calves in experimental group was 50%, and the incidence of recurrence of diarrhea was 50%; compared with control group, the feeding cost of experimental group during the experimental period was reduced by 32.52%. [Conclusion]It is concluded that the application of early weaning scheme of Chinese Holstein calves in alpine area has feasibility. The weaning scheme is helpful for increase benefit of enterprise and dairy farmers and is worthy of extending.