Abstract: The Genetics Experiment is a compulsory specialized basic course for undergraduates in bioengineering major. In this paper, the current situation and existing problems in teaching of Genetics Experiment were analyzed, and the corresponding reform measures were proposed. The practice of the teaching reform could be helpful for enhancing teaching efficiency and the quality of Genetics Experiment, improving learning initiative and innovation of undergraduates, cultivate applied talents with high quality, and could provide experiences for teaching reform of Genetics Experiment for undergraduates in bioengineering major.