Abstract: In the present study, the Cipangopaludina cahayensis was used as material to assess the tissues distribution of fluoride after short-term exposure. The Cipangopaludina cahayensis was exposed in the water containing 0, 40, 80 and 160 mg/L of fluoride for consecutive 10, 20 and 30 days, respectively. Compared with the control, the fluoride content in gastropods of Cipangopaludina cahayensis was increased with the extension of exposure duration. Although there were no significant differences in fluoride content in the visceral mass between the 10-day fluoride exposed Cipangopaludina cahayensis and control, significant differences were found between the 20--day and 30-day fluoride exposed Cipangopaludina cahayensis and control （P〈0.05）. With the extension of exposure duration, the fluoride content in gonad of exposed Cipangopaludina cahayensis was significantly increased compared with that of control （P〈0.05）. In the 20^th day of fluoride exposure, the fluoride accumulation was significantly increased with the increasement of water fluoride concentration, and