Abstract: [ Objective ]The aim of the present study was to assess the sedative and hypnotic effect of pachyman on mice. [ Methods ] The anticonvulsant effect of pachyman on mice was evaluated and its synergistic effect with pentobarbital was assessed. Five groups were included in this study. The blank control group, positive control group, and low-, middle-, high-dose group of pachyman were intragastricly administrated with 0.2 mL/（ 10 g. BW-d） of normal saline, 0.26 mg/（kg. BW. d） of diazepam, and 1.90 g/（kg ·BW ·d）, 3.61 g/（kg ·BW ·d）, 5.80 g/（kg ·BW ·d） of pachyman. [Results] High dose of pachyman exhibited anticonvulsant effect on mice with anticonvulsant efficiency of 60.00%, and the sleep duration of mice in high-dose group was increased to around 73.2 min under the synergy of pachyman and pentobarbital; the anticonvulsant efficiency of middle-dose and low-dose group of pachyman was 20.00% and 16.50%, respectively, and the sleep duration of mice in middle-dose group and low-dose group was increased to around 63.2 min and 55.7 min under the synergy of pachyman and pentobarbital, respectively. The antieonvulsant efficiency and sleep duration of mice in blank control group and positive control group was 0, 80.00% and around 48.1 min, 95.3 min respectively. [ Conclusion ] Pachyman has a dose-dependent sedative and hypnotic effect on mice.