Abstract: The problems that effective safety management system is deficient, safety and environmental facilities establishment is substandard, safety knowledge of staff associated with experimental animal management and production is scanty, management of chemical reagent and laboratory wastes is misconducted exist in management of animal experimental platform in colleges and universities. According to the current situation of animal experimental platform management in domestic colleges and universities, the authors suggest that the animal experimental platforms should establish and perfect the safety management system; for the undergraduates who apply for the admission of animal experimental platform, the training and examination of animal experiment safety should be enhanced; the management of hazardous chemicals and biological contaminants should be standardized; the comprehensive emergency plan should be made.