TCDCA对AA模型大鼠成纤维样滑膜细胞中三磷酸肌醇的影响

doi:10.12160/j.issn.1672-5190.2017.10.002

Animal Husbandry and Feed Science ›› 2017, Vol. 38 ›› Issue (10): 5-5.doi: 10.12160/j.issn.1672-5190.2017.10.002

Effect of TCDCA on Concentration of Inositol Trisphosphate in Fibroblast-like Synoviocytes in Rats with Adjuvant Arthritis

Guanqia＊Sangjide12,QIAN Ying-hong3,LI Pei-feng12,GUAN Hong12,HE Xiu-ling12,LIU Bo12,CAO Jin- shan＇,2,MAO Wei1,2（1.College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018, China; 2.Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease,Ministry of Agriculture, Hohhot 010018, China; 3.Inner Mongolia Academy of Agricultural and Animal Husbandry Science,Hohhot 010031, China）

Online:2017-10-20 Published:2017-10-20

Abstract

Abstract: The aim of the present study was to unravel the molecular mechanism underlining the therapeutical effect of TCDCA on adjuvant arthritis （AA） model rats. The intervention effect of TCDCA on inositol trisphosphate （IP3 ） concentration in fibroblast-like synoviocytes （FLS） of rats with AA was assessed quantitatively by using enzyme linked immunesorbent assay （ELISA）. The results showed that the IP3 concentration was found significantly increased in FLS of AA model rat at15 min （P〈0.05）, 30 min （P〈0.01） and 60 min （P〈0.05） after TCDCA treatment compared to control. The up-regulation of IP3 expression in FLS of rats with AA induced by TCDCA was observed in this study.

CLC Number:

S852.3

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URL: https://journal30.magtechjournal.com/xmysl/EN/10.12160/j.issn.1672-5190.2017.10.002

https://journal30.magtechjournal.com/xmysl/EN/Y2017/V38/I10/5

Effect of TCDCA on Concentration of Inositol Trisphosphate in Fibroblast-like Synoviocytes in Rats with Adjuvant Arthritis

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