Abstract: To determine the causative agents of the bacterial diseases of Zabuye salt goats in Pajiang Township of Zhongba County of Tibet,the clinical samples of fecal,blood,liver,spleen as well as the serous and fibrous exudates in chest cavity,abdominal cavity,pericardial cavity were recovered from the diseased goats to perform pathogenic agents isolation,identification and antimicrobial sensitivity testing.The results demonstrated that 97.14%(34/35)of the recovered samples were positive for the presence of Escherichia coli,indicating that Escherichia coli was the dominant pathogen associated with the infectious disease of the Zabuye salt goat lambs in this area;the isolates were highly sensitive to cefazolin,penicillin,amoxicillin,ceftazidime,florfenicol and cefradine.This study provides a diagnostic method and a medication plan for colibacillosis prevalent in Zabuye salt goat lambs in this region.