Abstract: Lamb diarrhea is a highly contagious disease and has a high mortality rate. Commonly, the occurrence this disease has no obvious seasonality and regularity. Most cases are clinically observed in newborn lambs showing obvious clinical symptoms of diarrhea. Causative factors associated with lamb diarrhea are complicated. A clear understanding of the etiological factors and scientific and effective prevention and treatment measures are conductive to control the lamb diarrhea. We mainly introduced the main etiological factors of diarrhea in lambs, in hoping to provide references for sheep farmers to control this disease.